RESUMO
Blue nevi are benign melanocytic lesions located in the deeper reticular dermis, consequence of failure of melanocytic migration into the dermal-epidermal junction from the neural crest. Lesions are usually asymptomatic and solitary, but may present in a multiple or agminated (grouped) pattern. The agminated subtype is formed when bluish-pigmented lesions cluster together in a well-defined area. Lesions can be flat or raised. We report the case of a patient who presented multiple bluish macules (1-3 mm in diameter) grouped on the left upper back. Dermoscopy and anatomic pathological examination were consistent with blue nevus.
Assuntos
Nevo Azul/patologia , Neoplasias Cutâneas/patologia , Dorso , Dermoscopia , Humanos , Masculino , Melanócitos/patologia , Pessoa de Meia-IdadeRESUMO
Abstract Gianotti-Crosti syndrome is a rare disease characterized by acral papular eruption with symmetrical distribution. It is a benign and self-limited disease; the symptoms disappear after two to eight weeks, without recurrences or scars. Skin lesions are usually asymptomatic. Prodrome might occur, suggesting upper respiratory infection, or constitutional symptoms. Diagnosis is eminently clinical, and this disease is associated with viral infections. Due to its rarity and low occurrence in adolescents and adults, we report a case of Gianotti-Crosti syndrome of a teenager.
Assuntos
Humanos , Feminino , Adolescente , Pele/patologia , Acrodermatite/patologia , Diagnóstico Diferencial , Exantema/patologiaRESUMO
Abstract The occurrence of multiple primary melanomas in a single individual is rare. Most commonly, malignant melanocytic lesions subsequent to the initial diagnosis of melanoma are secondary cutaneous metastases. We report a patient with gastrointestinal bleeding from gastric metastasis of cutaneous melanoma. During clinical evaluation and staging, we discovered a brain metastasis associated with 3 synchronous primary cutaneous melanomas. We suggest the research on the mutation in the cyclin-dependent kinase inhibitor 2A (CDKN2A) (INK4a) in such cases. We also emphasize the importance of clinical examination and dermoscopy of the entire tegument, even after a malignant melanocytic lesion is identified.
Assuntos
Humanos , Idoso , Neoplasias Cutâneas/patologia , Neoplasias Gástricas/secundário , Neoplasias Encefálicas/secundário , Melanoma/secundário , Neoplasias Primárias Múltiplas/patologia , Neoplasias Cutâneas/genética , Neoplasias Gástricas/genética , Biópsia , Neoplasias Encefálicas/genética , Dermoscopia , Inibidor de Quinase Dependente de Ciclina p18/genética , Melanoma/genética , Mutação , Neoplasias Primárias Múltiplas/genéticaRESUMO
Abstract Steatocystoma multiplex is a rare genetic disorder characterized by the presence of hamartomatous malformations at the junction of the pilosebaceous duct. It consists of encapsulated cystic lesions in the dermis, with adjacent sebaceous gland. When associated with inflammation, resembling hidradenitis, it is called steatocystoma multiplex suppurativa, a condition rarely reported. This is the first case of steatocystoma multiplex suppurativa reported in the Brazilian literature. Female patient, 23 years old, with papular and nodular cystic lesions that started in the armpits and groin, later spreading to the trunk, lower limbs, anticubital fossa, face and scalp. The presence of papular-nodular lesions associated with disseminated hidradenitis-like lesions in flexural areas and the histopathological diagnosis of steatocystoma defined the diagnosis of steatocystoma multiplex suppurativa.
Assuntos
Humanos , Feminino , Adulto Jovem , Esteatocistoma Múltiplo/patologia , Glândulas Sebáceas/patologia , Supuração , Biópsia , Hidradenite Supurativa/patologia , Doenças Raras/patologia , Diagnóstico Diferencial , Cisto Epidérmico/patologiaRESUMO
Abstract: Blue nevi are benign melanocytic lesions located in the deeper reticular dermis, consequence of failure of melanocytic migration into the dermal-epidermal junction from the neural crest. Lesions are usually asymptomatic and solitary, but may present in a multiple or agminated (grouped) pattern. The agminated subtype is formed when bluish-pigmented lesions cluster together in a well-defined area. Lesions can be flat or raised. We report the case of a patient who presented multiple bluish macules (1-3 mm in diameter) grouped on the left upper back. Dermoscopy and anatomic pathological examination were consistent with blue nevus.
Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias Cutâneas/patologia , Nevo Azul/patologia , Dorso , Dermoscopia , Melanócitos/patologiaRESUMO
Steatocystoma multiplex is a rare genetic disorder characterized by the presence of hamartomatous malformations at the junction of the pilosebaceous duct. It consists of encapsulated cystic lesions in the dermis, with adjacent sebaceous gland. When associated with inflammation, resembling hidradenitis, it is called steatocystoma multiplex suppurativa, a condition rarely reported. This is the first case of steatocystoma multiplex suppurativa reported in the Brazilian literature. Female patient, 23 years old, with papular and nodular cystic lesions that started in the armpits and groin, later spreading to the trunk, lower limbs, anticubital fossa, face and scalp. The presence of papular-nodular lesions associated with disseminated hidradenitis-like lesions in flexural areas and the histopathological diagnosis of steatocystoma defined the diagnosis of steatocystoma multiplex suppurativa.
Assuntos
Esteatocistoma Múltiplo/patologia , Biópsia , Diagnóstico Diferencial , Cisto Epidérmico/patologia , Feminino , Hidradenite Supurativa/patologia , Humanos , Doenças Raras/patologia , Glândulas Sebáceas/patologia , Supuração , Adulto JovemRESUMO
The occurrence of multiple primary melanomas in a single individual is rare. Most commonly, malignant melanocytic lesions subsequent to the initial diagnosis of melanoma are secondary cutaneous metastases. We report a patient with gastrointestinal bleeding from gastric metastasis of cutaneous melanoma. During clinical evaluation and staging, we discovered a brain metastasis associated with 3 synchronous primary cutaneous melanomas. We suggest the research on the mutation in the cyclin-dependent kinase inhibitor 2A (CDKN2A) (INK4a) in such cases. We also emphasize the importance of clinical examination and dermoscopy of the entire tegument, even after a malignant melanocytic lesion is identified.
Assuntos
Neoplasias Encefálicas/secundário , Melanoma/secundário , Neoplasias Primárias Múltiplas/patologia , Neoplasias Cutâneas/patologia , Neoplasias Gástricas/secundário , Idoso , Biópsia , Neoplasias Encefálicas/genética , Inibidor p16 de Quinase Dependente de Ciclina , Inibidor de Quinase Dependente de Ciclina p18/genética , Dermoscopia , Humanos , Melanoma/genética , Mutação , Neoplasias Primárias Múltiplas/genética , Neoplasias Cutâneas/genética , Neoplasias Gástricas/genéticaRESUMO
Gianotti-Crosti syndrome is a rare disease characterized by acral papular eruption with symmetrical distribution. It is a benign and self-limited disease; the symptoms disappear after two to eight weeks, without recurrences or scars. Skin lesions are usually asymptomatic. Prodrome might occur, suggesting upper respiratory infection, or constitutional symptoms. Diagnosis is eminently clinical, and this disease is associated with viral infections. Due to its rarity and low occurrence in adolescents and adults, we report a case of Gianotti-Crosti syndrome of a teenager.
Assuntos
Acrodermatite/patologia , Pele/patologia , Adolescente , Diagnóstico Diferencial , Exantema/patologia , Feminino , HumanosRESUMO
BACKGROUND: Some dermatoses affect the personal, professional and social lives of patients as a result of their unsightliness. It is important to pay appropriate attention in the overall evaluation of these individuals in order to implement a more effective therapeutic approach. OBJECTIVES: To evaluate the quality of life and the incidence of psychological distress in patients receiving care at a dermatology clinic. METHODS: A cross-sectional study. Following consultation, the Dermatology Life Quality Index (DLQI) and the Self Report Questionnaire (SRQ-20) were applied. RESULTS: One thousand patients were interviewed, 77.2% of whom were women. Most patients were in the 4160 year age-group. Dermatoses had no effect at all on the quality of life of 21.5% of patients, a small effect in 34.2% of cases, a moderate effect in 21.6%, a very large effect in 19.3% and an extremely large effect in 3.4% of patients. No statistically significant correlation was found between psychological distress and dermatoses. Comparison of the two questionnaires showed a statistically significant association between the presence of psychological distress and poorer quality of life (p<0.001). Patients with psychological distress reported that their skin condition had a very large or extremely large effect on their quality of life. CONCLUSION: This study highlights the fact that many skin diseases affect the quality of life and psychological state of the sufferer, affecting his/her health in general, the progression of the skin condition and the patient's response to therapy.